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KMID : 0816120000030010056
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Korean Journal of Pediatric Gastroenterolology and Nutrition
2000 Volume.3 No. 1 p.56 ~ p.62
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Serological and Histological Changes after Interferon Alfa Therapy in Children with Chronic Hepatitis B
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Ko Jae-Sung
Jang Ja-June
Seo Jeong-Kee
Chung Ju-Young
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Abstract
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Purpose : The aim of this study was to evaluate the efficacy and histologic changes of
interferon-alfa therapy on chronic hepatitis B virus infection in children.
Patients and Methods : Thirty five children aged 3∼16 years who were seropositive
for HBV DNA, HBsAg and HBeAg were enrolled. Interferon-alfa 2a (3.4 MU/㎡) were
given for 6 months. Serologic markers of viral replication was evaluated 1 year after
therapy. Post treatment liver biopsy was performed in 18 patients who showed serologic
response.
Results : Serum HBeAg and viral DNA became negative in 22 (63%) of treated
children at 12 months after therapy. Serum aminotransferase levels normalized in all of
the responders and HBsAg became negative in one responder. Horizontal transmission,
serum aminotransferase levels more than twice normal, and active inflammation on liver
biopsy were predictive factors for response to interferon therapy. Periportal piecemeal
necrosis, lobular activity, portal inflammation, fibrosis, and total histologic activity index
were reduced in responders.
Conclusion : In children with chronic hepatitis B, interferon alfa promotes loss of viral
replication and improves aminotransferase. Serologic response is associated with
improvement in hepatic histology.
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KEYWORD
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Hepatitis B, Interferon Alfa, Child,
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